Alu elements: an intrinsic source of human genome instability
نویسندگان
چکیده
منابع مشابه
Alu Elements and Human Disease
The Alu element Methylation of Alu Repeats DNA Demethylation Mechanism of Retrotransposition Alu elements and Disease Conclusion and Outlook Endnotes
متن کاملActive Alu retrotransposons in the human genome.
Alu retrotransposons evolved from 7SL RNA approximately 65 million years ago and underwent several rounds of massive expansion in primate genomes. Consequently, the human genome currently harbors 1.1 million Alu copies. Some of these copies remain actively mobile and continue to produce both genetic variation and diseases by "jumping" to new genomic locations. However, it is unclear how many ac...
متن کاملDiverse Splicing Patterns of Exonized Alu Elements in Human Tissues
Exonization of Alu elements is a major mechanism for birth of new exons in primate genomes. Prior analyses of expressed sequence tags show that almost all Alu-derived exons are alternatively spliced, and the vast majority of these exons have low transcript inclusion levels. In this work, we provide genomic and experimental evidence for diverse splicing patterns of exonized Alu elements in human...
متن کاملEstimating the retrotransposition rate of human Alu elements.
Mobile elements such as Alu repeats have substantially altered the architecture of the human genome, and de novo mobile element insertions sometimes cause genetic disorders. Previous estimates for the retrotransposition rate (RR) of Alu elements in humans of one new insertion every approximately 100-125 births were developed prior to the sequencing of the human and chimpanzee genomes. Here, we ...
متن کاملThe possible roles of human Alu elements in aging
The huge amount of knowledge about the organization and functions of genome structural units accumulated through genome research allows us to examine cell aging processes in detail and to test existing hypotheses of aging. One of the hypothesis currently of interest is that instability of the cell genome is one of the main causes of aging (Vijg and Suh, 2013). Putative causes of genome instabil...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2013
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2013.09.002